Clinical pharmacology studies

Capnographic monitoring allows duration of action of a bronchodilatating drug to be assessed.

Example : Measurement of effect duration of a bronchodilatating association (pirbuterol - ipratropium bromide) (AP) using nocturnal asthma monitoring (4 puffs preventive dose at bedtime).
The study was performed in 10 patients experiencing brittle asthma.

Capnographic monitoring during two double-blind consecutive nights after AP or Placebo (PCB).
Continuous assessment of S3 indice (alveolar plateau slope, n<0.5%/sec).
Difference is significant up to 6th hour.